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GOALORITHM / NFL

Preview · NFL

Research workspace

Arizona Cardinals vs San Francisco 49ers Prediction & Preview

Arizona Cardinals at San Francisco 49ers in the NFL, Sunday, September 27. Goalorithm's model makes a San Francisco 49ers win the likelier result at 88%. The preview covers the records, recent results and the injury report.

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Published September 27, 2026 · By the Goalorithm model desk

Final: San Francisco 49ers 36–30 Arizona Cardinals. Read the game analysis →

Preview

The Arizona Cardinals visit the San Francisco 49ers in the NFL on Sunday, September 27, with kickoff at 4:05 p.m. ET. The San Francisco 49ers come in after a win, while the Arizona Cardinals are coming off a loss.

What the model expects

The model gives the San Francisco 49ers an 88% chance to win and the Arizona Cardinals 12%. Those probabilities are estimates, not certainties; the San Francisco 49ers projection is at the model’s 88% ceiling. The model's likelier result is a San Francisco 49ers win.

The model projects 25.9 points for the San Francisco 49ers and 14.1 for the Arizona Cardinals, with 40 in all. Its projected margin is the San Francisco 49ers by 11.8 points.

Records and recent results

The San Francisco 49ers are 2-0 overall this season, with 62 points scored and 20 allowed in 2 games, and play in the NFC. The Arizona Cardinals are 1-1 overall this season, with 33 points scored and 45 allowed in 2 games, and play in the NFC. The San Francisco 49ers have the better record.

More NFL & college football news

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American footballPreview· college football

New Mexico State Aggies vs Florida International Panthers Prediction & Preview

New Mexico State Aggies at Florida International Panthers in college football, Wednesday, October 7. Goalorithm's model makes a Florida International Panthers win the likelier result at 78%. The preview covers the records and recent results.

Wed, Oct 7 · 7:30 PM ET

American footballPreview· college football

Missouri State Bears vs Western Kentucky Hilltoppers Prediction & Preview

Missouri State Bears at Western Kentucky Hilltoppers in college football, Thursday, October 8. Goalorithm's model makes a Missouri State Bears win the likelier result at 65.2%. The preview covers the records and recent results.

Predictions
Games
Standings

The San Francisco 49ers beat the Miami Dolphins 35-13 at home on September 20. The Arizona Cardinals lost 31-7 at home to the Seattle Seahawks on September 20.

Team news

For the San Francisco 49ers, Mike Evans and Jack Jones are questionable; Sam Okuayinonu, Ricky Pearsall, Nickolas Martin and Nick Zakelj are on injured reserve.

For the Arizona Cardinals, Roy Lopez and Max Melton are questionable; Will Johnson, Zach Carter, Trey Benson and Kitan Crawford are on injured reserve.

See every number for this game in the Game Center →

How this was written: an AI writer drafts the words from Goalorithm's own data. Every figure is filled in from our model and game records, never by the writer, and nothing we don't hold is guessed. Probabilities are model estimates, not certainties.

For informational/entertainment purposes only — not betting or financial advice. 21+. Gambling problem? Call 1-800-GAMBLER.

NFL

San Francisco 49ers vs Arizona Cardinals

Sun, Sep 27 · 4:05 PM ET

Goalorithm's model

San Francisco 49ers
88%
Arizona Cardinals
12%

Projected points

San Francisco 49ers
25.9
Arizona Cardinals
14.1
Total
40
Projected margin
San Francisco 49ers by 11.8

The margin and total are the model's own lines, not bookmakers'.

Open the Game Center

Thu, Oct 8 · 7:00 PM ET

American footballPreview· college football

Sam Houston Bearkats vs Liberty Flames Prediction & Preview

Sam Houston Bearkats at Liberty Flames in college football, Thursday, October 8. Goalorithm's model makes a Liberty Flames win the likelier result at 78.7%. The preview covers the records and recent results.

Thu, Oct 8 · 7:00 PM ET

American footballPreview· college football

South Florida Bulls vs UTSA Roadrunners Prediction & Preview

South Florida Bulls at UTSA Roadrunners in college football, Thursday, October 8. Goalorithm's model makes a South Florida Bulls win the likelier result at 73.8%. The preview covers the records and recent results.

Thu, Oct 8 · 7:30 PM ET